首页> 外文OA文献 >Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

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Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

机译：抗体产生细胞中α1,6-岩藻糖基转移酶（ FUT8 ）和GDP-甘露糖4,6-脱水酶（）的双重敲除：产生完全非生成的新策略-岩藻糖基化治疗性抗体，ADCC增强

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Shitara Kenya; Iida Shigeru; Wakitani Masako; Inoue Miho; Mori Katsuhiro; Imai-Nishiya Harue; Satoh Mitsuo;
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年度 2007
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1. Establishment of a GDP-mannose 4,6-dehydratase (GMD) knockout host cell line: A new strategy for generating completely non-fucosylated recombinant therapeutics [J] . Kanda Y, Imai-Nishiya H, Kuni-Kamochi R, Journal of Biotechnology . 2007,第3期

机译：建立GDP-甘露糖4,6-脱水酶（GMD）敲除宿主细胞系：产生完全非岩藻糖基化重组治疗药物的新策略
2. Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins [J] . Esser-Skala Wolfgang, Segl Marius, Wohlschlager Therese, Analytical and bioanalytical chemistry . 2020,第24期

机译：探索样品制备及数据评估策略，提高治疗性抗体和FC融合蛋白的药物产品中宿主细胞蛋白的鉴定
3. Double knockdown of α16-fucosyltransferase (FUT8) and GDP-mannose 46-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC [O] . Harue Imai-Nishiya, Katsuhiro Mori, Miho Inoue, 2007

机译：抗体产生细胞中α16-岩藻糖基转移酶（FUT8）和GDP-甘露糖46-脱水酶（GMD）的双重敲除：一种新的策略通过增强的ADCC产生完全非岩藻糖基化的治疗性抗体
4. Double knockdown of alpha1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC [O] . Harue Imai-Nishiya, Katsuhiro Mori, Miho Inoue, 2007

机译：抗体产生细胞中的α1,6-岩藻糖基转移酶（FUT8）和GDP-甘露糖4,6-脱水酶（GMD）的双重敲除：一种新的策略，通过增强的ADCC产生完全非岩藻糖基化的治疗性抗体

Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

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